Sodium Phenylbutyrate
Sodium 4-Phenylbutyrate
CAS: 1716-12-7
Molecular Formula: C10H11NaO2
Sodium Phenylbutyrate - Names and Identifiers
| Name | Sodium 4-Phenylbutyrate |
| Synonyms | SPB 4PBA PBNA 4PBA Sodium Tributyrate 4-Phenylbutyrate 4-PHENYLBUTYRATE, NA Sodium Phenylbutyrate SODIUM PHENYLBUTYRATE Sodium 4-Phenylbutyrate SODIUM 4-PHENYLBUTYRATE Sodium 4-phenylbutanoate Sodium 2-phenylbutanoate BENZENEBUTYRIC ACID SODIUM 4-PHENYLBUTYRIC ACID SODIUM 4-Phenylbutyric acid sodium PHENYL N-BUTYRATE SODIUM SALT Phenyl N-BUTYRATE Sodium salt 4-PHENYLBUTYRIC ACID SODIUM SALT 4-Phenylbutyric acid sodium salt benzenebutanoic acid, sodium salt |
| CAS | 1716-12-7 |
| EINECS | 605-612-7 |
| InChI | InChI=1/C10H12O2.Na/c1-2-9(10(11)12)8-6-4-3-5-7-8;/h3-7,9H,2H2,1H3,(H,11,12);/q;+1/p-1 |
| InChIKey | OBKXEAXTFZPCHS-UHFFFAOYSA-N |
Sodium Phenylbutyrate - Physico-chemical Properties
| Molecular Formula | C10H11NaO2 |
| Molar Mass | 186.18 |
| Melting Point | 224-226°C (dec.) |
| Boling Point | 272.9°C at 760 mmHg |
| Flash Point | 170.2°C |
| Solubility | H2O: ≥5mg/mL |
| Vapor Presure | 0.00288mmHg at 25°C |
| Appearance | White to slightly yellow solid |
| Color | white to beige |
| Storage Condition | room temp |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Phenylbutyrate is a well-known HDAC inhibitor, which increases the gene transcription of some genes and also exerts a therapeutic effect. Phenylbutyrate significantly attenuated MPTP-induced loss of striatal dopamine and loss of tyrosine hydroxylase-positive neurons. In prostate cancer cells, Phenylbutyrate attenuates the Bcl-X of an apoptosis antagonist (L), a DNA-dependent protein kinase for proteins repaired by double-strand breaks, prostate progression marker caveolin-1 and pro-angiogenic vascular endothelial growth factor expression. Phenylbutyrate and ionizing radiation Synergistically Induce Apoptosis in prostate cancer cells. |
| In vivo study | Phenylbutyrate significantly prolonged survival and improved clinicopathology and phenotype in transgenic G93AALS mice. Phenylbutyrate ameliorates histone deacetylation and induces expression of nuclear factor-κB(NF-κB) p50, phosphorylated inhibitory subunit, and beta-cell lymphoma 2(BCL-2) in G93A mice, but decreased the expression of cytochrome c and caspase. Phenylbutyrate expresses either the p50 of phosphorylated IκB, the p50 of translocated NF-κB to the nucleus, or the p50 of directly acetylated NF-κB. In a transgenic mouse model of Huntington's disease (HD), Phenylbutyrate increases brain histone acetylation and decreases histone methylation levels as assessed by immunocytochemistry and Western blot. In the striatum, Phenylbutyrate increases mRNA of the ubiquitin-proteasome pathway and down-regulates apoptotic cell death, the immunoreactivity of active caspase 3. |
Sodium Phenylbutyrate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | CY9057220 |
| HS Code | 29163990 |
Sodium Phenylbutyrate - Reference Information
| Biological activity | Sodium phenylbutyrate is a salt form of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid. Sodium Phenylbutyrate is a transcription regulator that functions by regulating HDAC activity to change chromatin structure. |
| Target | Value |
Last Update：2024-04-09 15:16:48
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Wechat: A2020071098
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Product Name: Sodium 4-phenylbutyrate Visit Supplier Webpage Request for quotationCAS: 1716-12-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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